| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.94 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Characterization of Amino Acid Stabilized Gold Nanoparticles |
| 초록 | Gold nanoparticles established as a subject of intense study in material engineering because of its wide application in electronic, optical and chemical aspects. A number of research on surface modification of gold colloids with terminally functionalized alkanethiols1 and arenethiols2 have been published in many scientific journals. Most of these works are performed in nonpolar organic solvent using tertiary ammonium ion as a phase transformer. However, the less attention has been given to the water-dispersibility, interaction with biological system, and its stability under physiologically conditions within living system, which provide broad applicationin biolabelling3, drug delivery, catalysis, sensors, and molecular makers. This work demonstrates the amino acids as a capping ligand for gold nanoparticles in water. Amino acids are the building blocks of protein and the sequence of which largely determines the physical as well as chemical behaviors of protein. On the other hand, presence of different alkyl group in an alpha-carbon atom determines the property of amino acid. In addition amino acid exists as a dipolar ion (Zwitterions) in aqueous solution due to which it avoids electrostatic aggregation. The broadening and the red shift of the characteristic gold plasmon shows some aggregation consequent to surface modification of gold nanoparticles with amino acids. Based on these realities, the stability of gold nanoparticles cappedby different types of amino acids, viz; l-Cysteine (Cys), l-Asparagine (Asn), and l-Leucine (Leu), was studied by varying the pH of the system. The broadening and the red shift of gold plasmon band showthe aggregation of nanoparticles with decrease in pH value as monitored by UV-visible spectrophotometer. Further the 1H NMR, TEM and TGA analysis were performed to characterize the fate of stabilization of amino acid capped gold nanoparticles. Acknowledgement This research was supported by the Korean Ministry of Science and Technology through the Center for Healthcare Technology Development. References 1. Templeton A. C., Hostetler M. J., Kraft C. T., Murray R.W., J. Am. Chem. Soc. 120 (1998), p. 1906. 2. Brust M., Fink J., Schiffrin D. J., Kiely C., J. Am. Chem.. Soc. (1995), p. 1655. 3. Munia Ganguli, J. Venkatesh Babu, Souvik Maiti, Langmuire 20 (2004), p. 5165. |
| 저자 | Aryal Santosh1, Remant B. K.C.2, Narayan Bhattarai3, 김철기2, 김학용4 |
| 소속 | 1Department of Bionanosystem Engineering, 2Chonbuk National Univ., 3Department of Bionanosystem Enginering, 4Department of Material Science and Engineering |
| 키워드 | Gold; Nanoparticles; Amino acid |
