| 초록 |
New thermosensitive nanogels, PNIPAAm-AA conjugated with chitosan, were designed and synthesized for the controlled release of the loaded drug.PNIPAAm nonogels containing carboxylic group on their surface was synthesized using emulsion polymerization. The carboxylic groups were applied to conjugate with the amino group of the low molecular weight water soluble chitosan (LMWSC). The particle size of synthesized nonogels was varied from 380 nm to 25 nm as temperature of the dispersed medium increased. LMWSC-conjugated nanogels of 2wt% MBA, crosslinking monomer, leaded to a stable aqueous dispersion at concentration of 1mg/1ml otherwise showed gel collapse temperature. The effect of temperature on the dynamic behavior of the PNIPAAm chains were also studied by 1H NMR and fluorescent measurements. |
