| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
고분자 구조 및 물성 |
| 제목 |
Effect of C60 Fullerene on the Duplex Formation of i-Motif with Complementary DNA in Solution |
| 초록 |
The structural effects of fullerene on i-motif DNA were investigated by characterizing the structures of fullerene-free and fullerene-bound i-motif DNA, in the presence of complementary DNA and in solutions of varying pH, using circular dichroism and synchrotron small-angle X-ray scattering. To facilitate a direct structural comparison between the i-motif and duplex structures in response to pH stimulus, we developed atomic scale structural models for the duplex and i-motif DNA structures, and for the C60/i-motif DNA hybrid associated with the complementary DNA strand, assuming that the DNA strands are present in an ideal right-handed helical conformation. We found that fullerene shifted the pH-induced conformational transition between the i-motif and the duplex structure, possibly due to the hydrophobic interactions between the terminal fullerenes and between the terminal fullerenes and an internal TAA loop in the DNA strand. |
| 저자 |
진경식1, 신수련2, 김선정2, 안변철1, 진상우1, 노예철1, 이문호1, 황정연1, 장성덕1, 임재홍1, 김효윤1
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| 소속 |
1포항공과대, 2한양대 |
| 키워드 |
i-motif; molecular structure; small-angle X-ray scattering
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| E-Mail |
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