| 학회 |
한국공업화학회 |
| 학술대회 |
2014년 가을 (11/12 ~ 11/14, 엑스코(대구)) |
| 권호 |
18권 2호 |
| 발표분야 |
나노-포스터 |
| 제목 |
Efficient DNA vaccination by introducing chemotatic peptide loaded microspheres and polyplexs with multi-layered microneedle |
| 초록 |
The approach of gene delivery with microneedles has recently been withdrawn much attention. Despite superior capability of microneedles delivering DNA into the dermal tissues, release and cellular uptake of the released DNA after microneedle-based administration have not been clearly studied. In this study, we fabricated polyplex-releasing multilayered microneedles additionally coated with microspheres containing a chemo-attractant for recruiting professional antigen presenting cells such as macrophages. The microspheres can be released from the needle body and localized in the dermis area where chemo-attractant slowly released. The ability of the microneedle-based cutaneous gene delivery system for attracting antigen presenting cells and improving DNA vaccination was tested. |
| 저자 |
김낙원1, 이민상1, 이정은1, 조용우2, 정지훈1
|
| 소속 |
1성균관대, 2한양대 |
| 키워드 |
DNA vaccination; microneedle; chemotatic effect
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| E-Mail |
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