| 초록 |
Recently gadolinium (Gd) chelates have been extensively studied as a radio-sensitizer in neutron capture therapy (NCT) of several cancers. However, Gd chelates have merits like poor selective cell labeling, short blood circulation time, and toxicity. In this work, nano-sized Gd2O3@SiO2 nanoparticles were prepared by using the polyol protocol which can control the crystallinity and prevent the aggregation of Gd2O3 particles, and the surface of Gd2O3@SiO2 nanoparticles was modified with phosphorylcholine moiety to enhance the circulation time and in vivo stability for MRI-active Gd-NCT applications. (This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0012479)) |
