| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of Polymeric Nanoparticles from a Poly(ethylene glycol)-Poly(phenylalanine)-Poly(D,L-lactic acid) Triblock Copolymer |
| 초록 |
Biodegradable polymeric nanoparticles have been extensively studied as a drug delivery system for several decades. In this study, a poly(ethylene glycol)-poly(phenylalanine)-poly(D,L-lactic acid) triblock copolymer was synthesized. Nanoparticles were prepared by a surfactant-free emulsion-solvent evaporation method from the tri-block copolymer. The poly(phenylalanine)-poly(D,L-lactic acid) blocks formed a hydrophobic core of the nanoparticle, while the poly(ethylene glycol) chains created a hydrophilic corona. The poly(phenylalanine) blocks were expected to form an interface layer and stabilize the nanoparticle via hydrogen bonding between the amide groups and π-πinteraction between the phenyl groups. The release behavior of 1-aminopyrene was investigated. |
| 저자 |
이현표, 장지영
|
| 소속 |
서울대 |
| 키워드 |
drug delivery; polymeric nanoparticle
|
| E-Mail |
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