| 초록 |
Hydrogels are of great interest as potential biomaterials for sustained delivery of various therapeutic agents. In this study, a novel blend system hydrogel was designed and evaluated. To utilize thiol-disulfide exchange chemistry, Pluronic F127 was simply modified into two types of functional groups, thiol and pyridyl disulfide, respectively. In physiological environment, gelation occurs firstly via micelle packing mechanism of Pluronic F127 and thiol-disulfide exchange reaction which can be thought as a driving force of mechanically stable hydrogel system happens at the shell of micelles. The resultant hydrogel showed significantly different sol-gel phase transition behaviors with much lower critical gelation temperatures than unmodified Pluronic hydrogels. By in vitro gel dissolution rate experiment and doxorubicin release profile, it can be expected that therapeutic molecules are released out for about one month when incorporated in this blend system hydrogel. |
