| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Metasequoia glyptostroboides extract potentiates anti-cancer effects through intrinsic apoptosis pathways |
| 초록 |
This study was conducted to evaluate the anticancer effect of M. glyptostroboides floral cone extracts prepared with various organic solvents such as n-hexane, dichloromethane (DME), chloroform and ethyl acetate against cervical cancer. Cervical cancer cell line HeLa cells showed higher cytotoxicity than normal cell control, COS-7, under the administration of 50 µg/ml of DME extract. Also, the number of cells at the sub-G1 phase, which indicates apoptotic cells, was increased approximately fourfold upon treatment with the DME and CE extracts compared with that in the negative control. Comprehensive results including GC–MS analysis suggest that DME organic extract derived from the floral cones of M. glyptostroboides induces the apoptosis pathway, which allows the extract of M. glyptostroboides floral cones to become a potential material for anticancer drugs targeting apoptosis avoidance. |
| 저자 |
김관우1, 이후민1, 오철우1, 김수지1, 김형교2, Debasish Kumar Dey3, Vivek K. Bajpai4, 한영규4, 허윤석1
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| 소속 |
1인하대, 2젠퓨어, 3대구대, 4동국대 |
| 키워드 |
Metasequoia; Extract; Anti-cancer; Apoptosis
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| E-Mail |
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