| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Suppression of initial burst in PLGA Microspheres using polymeric complex |
| 초록 |
ET (Escitalopram) encapsulated PLGA microspheres can be released for a long time, but industrial application is difficult due to initial burst. The goal of this study is to complex ET with pGA to sustained release. ET-pGA was prepared by ionic interaction between escitalopram oxalate and poly-galactronic acid. This was encapsulated in a PLGA microspheres by an s/o/w solvent evaporation method. As a result of analysis by UV-spectroscope and SEM microscope, the loading efficiency of microspheres was about 20% and the encapsulation efficiency was 85%. It was confirmed that ET-pGA-loaded microspheres were reduced in initial burst relative to the control group. The reason is that the drug-polymer chain was delayed in dissolution time in PBS. These properties are expected to lead to a stable sustained release of the drug in the polymeric complex form of ET-pGA. |
| 저자 |
양태경1, 강석희1, 최호석2, 신병철1
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| 소속 |
1한국화학(연), 2충남대 |
| 키워드 |
Biodegradable polymer; PLGA microspheres; Drug delivery system; escitalopram
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| E-Mail |
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