| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
[생체재료] 차세대 생체재료: 오가노이드 기술과 조직재생소재 |
| 제목 |
Engineered 3D Skeletal Muscle for Identifying Therapeutic Myokines |
| 초록 |
A growing amount of evidence classifies skeletal muscle as an endocrine organ that can release secretory factors, called myokines. Despite the wealth of studies reporting beneficial effects of these putative factors, the exact mechanistic actions of myokines remain elusive due to technical challenges in the identification. Thus, we engineered a 3D microphysiological system that recapitulates native properties of contracting myofibers and integrated it with a biorthogonal proteome labeling system that can detect newly synthesized proteins. Our 3D muscle construct not only enables precise identification of bona fide myokines but also puts us one step closer to developing myokine-based therapy for late-onset lifestyle disorders or for patients in need of exercise therapy but cannot perform physical activities. |
| 저자 |
Gunjae Jeong1, Younghoon Son2, Sung Jin Park3, Young Charles Jang3
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| 소속 |
1Georgia Tech, 2Emory Univ., 3Georgia Tech & Emory |
| 키워드 |
Skeletal muscle; Myokine; Muscle-on-a-chip
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| E-Mail |
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