| 학회 | 한국화학공학회 |
| 학술대회 | 2017년 가을 (10/25 ~ 10/27, 대전컨벤션센터) |
| 권호 | 23권 2호, p.1732 |
| 발표분야 | 생물화공 |
| 제목 | Aptamer Grafted Hydroxyapatite for Promoting Bone Regeneration and Angiogenesis |
| 초록 | Aptamers are short oligonucleotide structures that are capable of targeting molecules and proteins. Aptamers apply to therapeutic agents that can capture specific target molecules with stability, non-toxicity, and non-immunogenicity. Hydroxyapatite is a typical material used for bone grafting due to its structural and chemical similarity to the mineral phase of hard tissue. Hydroxyapatite is not only used as an alternative to bone grafting, it is also used to promote bone regeneration by modifying the surfaces. In this study, we have developed the novel aptamer conjugated hydroxyapatite (Apt-HA) that promotes bone regeneration and angiogenesis. 3R02 bivalent aptamer, which specifically captures the vascular endothelial growth factor (VEGF) protein, was used. Certain cross linkers were used to graft the aptamers on the surface of hydroxyapatite, which was identified by the FT-IR spectrometer. Apt-HA was tested for its ability to capture VEGF protein, which was observed under a fluorescence microscope using FAM-labeled aptamers. |
| 저자 | 손재우, 최종훈 |
| 소속 | 중앙대 |
| 키워드 | 생물화공 |
| 원문파일 | 초록 보기 |
