| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Shell-crosslinked Magnetic Nanoparticles for Targeted Labeling and Imaging |
| 초록 |
We prepared highly stable and functionalized magnetic nanoparticles for targeted labeling and imaging applications. A library of functionalized PEGs was screened to transfer and stabilize organic synthesized iron oxide nanoparticles (IONPs) in aqueous solution by a vacuum-drying method. For preparing highly stable nanoparticles and their specific targeting, the coated PEG on IONPs were crosslinked using hyaluronic acid. The shell-crosslinked magnetic nanoparticles exhibited high stability in aqueous solutions with various pH and high salt concentrations for over a month, compared to IONPs coated only with 6PEG-NH2. The shell-crosslinked magnetic nanoparticles also showed enhanced internalization into cells expressing CD44 receptor, such as mesenchymal stem cells, by specific uptake. The shell-crosslinked magnetic nanoparticles showed high application potentials for stem cells and trafficking, or targeted cancer imaging. |
| 저자 |
정현정, 박태관
|
| 소속 |
한국과학기술원 |
| 키워드 |
Shell-crosslinking; Magnetic Nanoparticles; Imaging
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| E-Mail |
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