| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vitro degradation and cytotoxicity of Biodegradable Elastic Poly(glycolide-co-L-lactide-co-ε-caprolactone)(PGLCL) for Mechano-Active Tissue Engineering. |
| 초록 |
There have been lots of studies on biodegradable aliphatic polyesters which have proper degradability and mechanical properties for tissue engineering applications. We synthesized new series of tri-component copolymers by ring opening copolymerization of cyclic lactons, i.s. glycolide, L-Lactide and ε-caprolactone, in the presence of stannous octoate as a catalyst. In this study, we determinded the biodegradability and cytotoxicity of PGLCL copolymers, we performed in vitro degradation tests in PBS for 12 weeks and observed changes of molecular weight, gross weight and compositions. And we also studied cytotoxicity by WST assay. The results suggest principles that could be controlled by changing the monomer content thus increasing the range of applications to mechano-active tissue engineering depending on demands in mechanical properties. And the PGLCL doesn’t have cytotoxicity with L929 fibroblasts. |
| 저자 |
이선희1, 김수현1, 김상헌1, 정영미1, 임종주2
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| 소속 |
1한국과학기술(연), 2동국대 |
| 키워드 |
Biodegradable polymer; Elastic polymer; Tissue Engineering
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| E-Mail |
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