| 초록 |
The micro-sized hydrophilic patches existed in the superhydrophobic background surfaces of the desert beetle allow to create arrays of quasi-spherical aqueous droplets that are stably attached on surfaces. Here, the hydrophilic modification of the superhydrophobic surface was readily achieved by polydopamine coating, a mussel-inspired versatile coating method to fabricate the biomimetic platform called spheroform. We demonstrated that various sizes of aqueous droplets can be hung on the spheroform with maintaining quasi-spherical geometry. Taking advantage of this unique surface property, we produced therapeutic cellular spheroids. The cellular spheroids formed on spheroform exhibited superior functions due to the unique quasi-spherical environments. Results showed that the glucose sensitivity of islet cell spheroids was increased by 200%, and secretion of vascular endothelial growth factor from mesenchymal stem cell spheroids was enhanced by 300% than conventional culture methods. |
