| 초록 |
Herein, a near-infrared light-induced redox-sensitive hydrogel was synthesized by incorporation of IR825 loaded-polymer dot (PD-IR825) into thermosensitive poly(N-isopropylacrylamide) hydrogel for study of nanoparticles mobility inside network via reversible temperature memory by redox changes. PD-IR825 inside the hydrogel network performed fluorescent and photothermal properties, exhibiting shrinking in volume behavior upon NIR at redox condition. The photothermal effect, fluorescence, and microstructure of hydrogel could be controlled under NIR on/off cycles. Furthermore, MDAMB cancer cells were incubated with composite hydrogel and exogenous GSH showed enhanced photothermal effect, that effectively killed cancer cells under NIR laser. Hence, light-induced redox-sensitive composite hydrogel has shown its potential in photothermal cancer treatment with study nanoparticles mobility inside hydrogel networks. This work was supported by Korea National University of Transportation in 2019. |
