| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Identification of 4-bit Hydrogel Barcode using Micropore Device |
| 초록 |
Encoded hydrogel microparticles has great potential for biomolecule assays for their multiplexibility and solution-phase reaction kinetics. However, the methods currently used for recognizing assigned codes on the particles and their binding states are very slow or require a complicated system. Here, we report the precise decoding of a shape-modulated hydrogel barcode particle using a micropore fluidic device. Using an electrical simulation, we deduced the optimal pore geometry that yields the maximal sensing signal. We fabricated hydrogel particles with different dimensions and prepared the micropore device along with a fluidic cell and a patch clamp. Accordingly, we experimentally determined the most appropriate shape of the hydrogel barcode particle that allows efficient differentiation between a 0 code and a 1 code. Thus, we successfully decoded 4-bit hydrogel barcode particles with high speed and high accuracy. |
| 저자 |
배수현, 류지헌, 김현웅, 송창우, 신세현, 봉기완, 한창수
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| 소속 |
고려대 |
| 키워드 |
Low-aspect-ratio micropore sensor; Hydrogel barcode particle; Multiplexed detection
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| E-Mail |
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