| 초록 |
Hydroxyapatite (HAp) is a material mainly used for bone graft component. However, sintered HAp has poor mechanical properties and difficulty for cell adhesion and proliferation with irregular pore structures. Porous 3D scaffolds for bone tissue regeneration were fabricated by mixing poly(glycolic acid) (PGA) and HAp with 3D printing technique. This technique can induce improved bone conduction ability with similar mechanical strength. Through the cell proliferation test, PGA/HAp scaffolds with a 400 μm pore size were accepted. PGA scaffolds containing 12.5 wt% HAp showed significant compressive strength, osteogenesis, mineralization and biodegradation. In in vivo animal test using rabbit bone defect model, the PGA/HAp scaffolds exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a possible option to promote patient-customized bone regeneration. |
