| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 |
13권 2호, p.1369 |
| 발표분야 |
고분자 |
| 제목 |
Synthesis and characterization of pH sensitivePEG-b-PDPG block copolymer |
| 초록 |
pH sensitive polymeric micelles can strengthen the anti-tumor efficiency of a drug by accumulating in the target area. In order to synthesize pH sensitive block copolymer, we synthesized PEG-b-PBLG(Poly Benzyl-L-Glutamate) via polymerization of N-carboxyanhydrides. According to substituting side groups by aminolysis, PEG-b-PDPG(Poly (N'-DiisoPropyl) ethyl-Glutamine) was synthesized. The chemical structure of PEG-b-PBLG and PEG-b-PDPG was characterized by 1H NMR spectroscopy. The molecular weights of the synthesized polymer was measured by a gel permeation chromatography (GPC). The pH sensitivity of polymeric micelles was determined by fluorescence using pyrene as a probe. The particle size of polymeric micelles was measured by dynamic light scattering measurements. |
| 저자 |
한종권, 김민상, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
pH sensitive; aminolysis; micelles; block copolymer
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| E-Mail |
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| 원문파일 |
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