| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
ED-B targeting peptide aptamer conjugated SPION (BPBEDB-SPIONs) for brain tumor MR imaging |
| 초록 |
Here, we developed a novel EDB-targeted peptide aptamer conjugated Superparamagnetic iron oxide nanoparticles (BPBEDB-SPIONs) for brain tumor diagnosis. Our research group found EDB targeting peptide aptamer. In this research, we designed amphiphilic polymer coated SPION which contained EDB targeted peptide aptamer conjugated DSPE-PEG2000,DSPE-PEG2000-Methoxy and Rhodamine-DSPE via nanoemulsion method. Comparing with non-targeting SPION,BPBEDB-SPIONs showed higher uptake in EDB over-expressing U87MG cell line. In vivo experiments, EDB peptide conjugated SPION was accumulated more at tumor site compared to non-targeting SPION in U87MG tumor bearing mice. MRI signal at U87MG tumor site of BPBEDB-SPIONs group was lower, indicating the specific targeting and uptake of BPBEDB-SPIONs. Furthermore, we confirmed that the BPBEDB-SPIONs was accumulated only at EDB expression site. These results suggests that our BPBEDB-SPIONs has high potential as MR imaging of EDB over-expressing tumor. |
| 저자 |
박진호1, 전상용1, 유미경1, 김성현1, 이광렬2, 김민식2, 정용연3, 이인현1, 페이어1
|
| 소속 |
1광주과학기술원, 2고려대, 3전남대 |
| 키워드 |
Peptide; SPION; MRI; Cancer diagnosis
|
| E-Mail |
|
