| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
나노_포스터 |
| 제목 |
Silver Nanoshell Biosensors for SERS-based Biomarker Detection |
| 초록 |
It is of importance to detect protein biomarkers in blood in a sensitive and multiplexed manner for the early and accurate diagnosis of diseases. Herein, we report an approach for the synthesis of silver nanoshells (AgNSs) as surface-enhanced Raman scattering (SERS) nanoprobes for the multiplex and sensitive detection of the biomarkers specific for Alzheimer’s disease (AD). AgNSs rapidly formed on the surface of silica nanoparticles without pre-deposition of seed metals. As-prepared AgNSs were very uniform in size (100 nm), and had 2 nm of nanogaps. AgNSs exhibited strong SERS signals with an enhancement factor of 1.7x107. The antibody-conjugated AgNSs were applied for the sensitive and multiplex detection of AD biomarkers, including Aβ40 and Aβ42. It was found that the AgNS probe was able to detect the target proteins at the concentration as low as 100 fg/mL. |
| 저자 |
황인준, 양진경, 임다빈, 김혜인, 최찬희, 김종호
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| 소속 |
한양대 |
| 키워드 |
Surface Enhanced Raman Scattering; Alzheimer's Disease; Biosensors; Plasmonic sensors
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| E-Mail |
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