| 초록 |
When using 3D bioprinting to build large constructs, the more serious hypoxia can be operated on cells in the core of the constructs due to the greater a size. Therefore, a space within the structure is used to improve the hypoxia. However, mechanical properties of its construct are weakening due to the empty space. Therefore, we designed a concept for assembling the delicate construct with other precise blocks. In addition, the each block is given different biodegradability. Hence, vascularization is promoted into the block with a rapid degradation rate. We optimized printing parameters to use a biocompatible alginate. Then, we confirmed sufficient mechanical properties enough to support cells. The assembly was highly strong with the external force. Moreover, the cell viability was approximately equal to non-printed cells. We are in experiments such as measurement of hypoxia, degradation test and so on. If our concept is confirmed, the assembling blocks would be a promising platform. |
