| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Folate-PEG-Superparamagnetic Iron Oxide Nanoparticles labeled with Cy5.5for Lung Cancer Imaging |
| 초록 |
To develop a functionalized iron oxide nanoprobe for lung cancer imaging, the folate-conjugated poly(ethylene glycol)(Fol-PEG) was immobilized onto the surface of superparamagnetic iron oxide nanoparticles (SPIONs) and labeled with near-infrared fluorescence dye Cy5.5. Fol-PEG-SPIONs was characterized by DLS, TEM, XRD. In vitro intracellular uptake of the Fol-PEG-SPIONs-Cy5.5 was assessed by FACS. Their toxicity was also assessed in vitro and in vivo. Further, we checked to in vivo imaging after intravenous administration in a lung cancer model mouse. Fol-PEG-SPIONs-Cy5.5 exhibited lower cytotoxicity, and enhanced targeted delivery efficiency to cancer cells both in vitro and in vivo. NIR fluorescence imaging demonstrated that tumor sites were better clearly identified upon systemic injection of Fol-PEG-SPIONs-Cy5.5 than PEG-SPIONs-Cy5.5 without folate. These results suggest that Fol-PEG-SPIONs-Cy5.5 can be exploited as in vivo optical imaging agent for lung cancer diagnosis. |
| 저자 |
유미경1, 임황태1, 강호림1, 허성웅1, 이상준2, 박인규2, 정환정3, 조명행1, 조종수1
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| 소속 |
1서울대, 2전남대, 3전북대 |
| 키워드 |
nanoprobe; iron oxide nanoparticles; Cy5.5; lung cancer; optical imaging
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| E-Mail |
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