| 초록 |
Although various anticancer drugs have been developed, their successful treatments are still far off due to the unintended effects on normal cells. Thus, we have developed efficient drug delivery system for cancer therapy by utilizing polymerized paclitaxel(pPTX), beta-cyclodextrin(βCD) and superparamagnetic iron oxide nanoparticle(SPION). Though PTX is a well-known anticancer drug on variable cancers, it has poor solubility in blood. In order to overcome this problem, we employ host-guest interaction between βCD and pPTX. In addition, SPION was utilized for magnetic-guided delivery method which improve drug targeting efficiency. SPION is prepared by using co-precipitation method and polymer-conjugated paclitaxel is developed according to the previously reported method by our group. The drug-conjugated-nanoparticle formation was confirmed and its biocompatibility was evaluated. |
