| 학회 | 한국화학공학회 |
| 학술대회 | 2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 | 15권 2호, p.2148 |
| 발표분야 | 재료 |
| 제목 | Functionalization of mesoporous silica particles for drug delivery |
| 초록 | Mesoporous silica particles with different morphology and functional groups were prepared using the tetraethlyorthosilicate (TEOS) as precursor and the cetyltrimethylammonium bromide (CTAB) and poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) as templates. The surface of the synthesized particles was functionalized using different functional groups, i.e., 3-aminopropyltriethoxysilane (APTES), N-[3-(trimethoxysilyl)propyl]-ethylenediamine, 2-(4-chlorosulfonylphenyl)-ethyltrimethoxysilane, and acetic acid. These particles were characterized by scanning electron microscopy (SEM), transmission electron microcopy (TEM), and nitrogen sorption method. To test these particles as carriers for drug delivery, ibuprofen was loaded onto each particles modified with different functional groups. The release of ibuprofen from different mesoporous particles in phosphate buffer solution (PBS) was monitored using the UV-vis. spectroscopy. The results provide the understanding on the interaction between the drug and carrier particles. |
| 저자 | 이덕규, 이강택 |
| 소속 | 연세대 |
| 키워드 | drug delivery; mesoporous silica; ibuprofen |
| 원문파일 | 초록 보기 |
