| 학회 | 한국화학공학회 |
| 학술대회 | 2009년 봄 (04/23 ~ 04/24, 광주 김대중컨벤션센터) |
| 권호 | 15권 1호, p.903 |
| 발표분야 | 재료 |
| 제목 | Mesoporous silica as a carrier in the drug delivery system |
| 초록 | Mesoporous silica particles with different size and morphology were prepared using the tetraethlyorthosilicate (TEOS) as precursor and the cetyltrimethylammonium bromide (CTAB) and poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) as templates.The surface of the synthesized particles was functionalized with the amine group using the 3-aminopropyltriethoxysilane (APTES). These particles were characterized by scanning electron microscopy (SEM), transmission electron microcopy (TEM), nitrogen sorption, thermogravimetric analysis (TGA), and X-ray diffraction (XRD). To test these particles as carriers for drug delivery, ibuprofen was loaded onto both the unmodified and modified particles. The release of ibuprofen from different mesoporous particles in phosphate buffer solution (PBS) or stimulated body fluid (SBF) was monitored using the UV-vis. spectroscopy. The results will provide the understanding on the interaction between the drug and carrier particles. |
| 저자 | 이기태, 이덕규, 이강택 |
| 소속 | 연세대 |
| 키워드 | mesoporos silica; SBA-15; ibuprofen; drug delivery system |
| 원문파일 | 초록 보기 |
