| 초록 |
It is imperative to identify and develop new modalities of antibiotic treatment to invasive bacterial infections. Herein, we describe an infection-specific peptide (sequence: CARG), which we identified by in vivo phage display screening in mice with lung infection caused by S. aureus. The CARG peptide shows high binding affinity to infected lung lesions, and specifically homes to the sites of infection when systemically injected. The peptide enhances accumulation of systemically administered nanoparticles loaded with antibiotic vancomycin, and significantly improved the antibiotic efficacy to treat the infection compared to free vancomycin administration. This study demonstrates that the CARG-targeted nanoparticles could be used for systemic delivery of antibacterial chemotherapeutics, and the resulting nanoplatform opens up a convenient and safe strategy to treat bacterial infections. |
