| 초록 |
Simultaneous diagnosis of cancer by CT and MRI are widely popular. However, each of them has some disadvantages. These problems could be overcome by the combination of CT and MRI. Therefore, it will be more desirable to synthesize a multi-functional probe with two different imaging functions, monitored by CT and MRI. Here, multi-imaging nanoparticle was synthesized. Sense and anti-sense oligodeoxynucleotides (ODNs) were used to link the iron oxide and gold particles together when hybridized. For extending the circulation time of the formulated nanoparticles, their surface was coated with poly ethylene glycol (PEG). Physicochemical properties of particles were characterized by TEM, DLS, and Zeta-potential. The sizes of particle could be adjusted by varying the amount of sense or anti-sense ODNs attached to either particle. It was demonstrated in this study that the multi-imaging nanoparticles formed by linking gold and Iron oxide possessed dual imaging property by CT and MRI. |
