화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center))
권호 21권 1호
발표분야 생체재료
제목 Biodegradable coating and local delivery of tauroursodeoxycholic acid for coronary stent application
초록 Coronary artery diseases are usually treated by stent implantation. Currently used bare metal stent (BMS) and drug-eluting stent (DES) showed an excellent clinical efficacy. However, over a long-term follow-up, BMS and DES causes restenosis due to the vascular smooth muscle cell (VSMC) hyperplasia and late-thrombosis caused by delayed re-endothelialization due to drug toxicity, respectively. Tauroursodeoxycholic acid (TUDCA) has been reported to have an effect on inhibiting neointimal hyperplasia by up-regulating apoptosis of VSMCs. In addition, TUDCA promotes proliferation and migration of endothelial adult and progenitor cells. In this study, we utilized TUDCA as an alternative drug of currently commercialized drugs such as sirolimus. With poly lactic-co-glycolic acid (PLGA) coating, the drug could be locally delivered to the stented site with a steady release. To the best of our knowledge, it can be a promising way to promote blood vessel recovery without side effects of drug.
저자 김대환1, 박광숙1, 이규백2, 한동근1, 정윤기1
소속 1한국과학기술(연), 2고려대
키워드 tauroursodeoxycholic acid; TUDCA; PLGA; stent
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