| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
Comparison of metal-supported extracellular matrices for cardiovascular applications |
| 초록 |
Cardiovascular metallic implants have been widely treated for patients with narrowed blood vessels. However, these cause vascular injury and erosion of endothelium due to their poorly adhesive surfaces, such as inflammation and thrombosis. To overcome these disadvantages, we employed a sequential coating of polydopamine (pDA) and fibronectin (FN) to a metal surface (CoCr). The modified surfaces strongly anchored with extracellular matrices (ECMs) through decellularization were characterized by SEM, FTIR and immunostaining. We compared various cells derived ECMs using genetic and proteomic analyses to investigate cell-dependent effects on cells. It is believed that the versatile sequential coating with pDA and FN will be a new approach for coating of ECMs and the metal-supported ECMs will be a good model for implantable metallic implants. |
| 저자 |
정미진1, 박광숙1, 김익환2, 한동근1, 정윤기1
|
| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
stent; various cells derived extracellular matrices
|
| E-Mail |
|
