| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
In Vitro Degradation and Cell Growth of Porous PU/PEGDA IPN Scaffolds |
| 초록 |
A particulate-leaching method was developed to prepare highly porous biodegradable polymer scaffolds. It involves the casting of polymer/salt composite followed by the dissolution of the salt. Interpenetrating polymer networks (IPNs) combining polyurethane (PU) and poly (ethylene glycol) diacrylate (PEGDA) networks were prepared using simultaneous polymerization. Polyurethane was synthesized from biocompatible and biodegradable polycaprolactone diol and the hydroxyl group of PEG was substituted to crosslinkable acrylate group. Since the IPN we synthesized has good mechanical properties, biodegradability and biocompatibility, porous PU/PEGDA IPNs of controlled porosity were prepared with sodium chloride sieved particles. The mechanical properties and in vitro degradation test was conducted followed by evaluating the effect of pore size and composition of the scaffold on cell’s (fibroblast) proliferation and growth. |
| 저자 |
김화, 김성철
|
| 소속 |
한국과학기술원 |
| 키워드 |
IPN; scaffolds; cell seeding; degradation
|
| E-Mail |
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