| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
A New Class of Bio-Inspired In Situ-Forming Long-lasting Themo-Sensitive Injectable HA/Pluronic Hydrogels Using Dopamine-Thiol Reaction |
| 초록 |
Hydrogels based on hyaluronic acid (HA) are widely studied as biocompatible and biodegradable materials for cartilage regeneration, wound healing and post-surgical anti-adhesion. However, poor mechanical properties exclude many biomedical applications. Although many approaches aimed to reduce the problems, synthesis of rapid in situ-gelling injectable HA-based hydrogels is still challenging. Thermo-gelling injectable hydrogels based on poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) have been used for injectable cell therapy, tissue regeneration, protein delivery and wrinkle filler applications. Here, we synthesized HA-dopamine conjugate (HA-DN) and thiol-terminated Pluronic (Plu-SH) and developed a bio-inspired in situ-forming thermo-sentivie long-lasting injectable hydrogel by combining HA-DN and Plu-SH using dopamine-thiol reaction for rapid and robust crosslinking under physiological conditions. |
| 저자 |
이유한1, 이해신2, Phillip B. Messersmith2, 박태관1
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| 소속 |
1한국과학기술원, 2Northwestern Univ. |
| 키워드 |
Bio-Inspired; Injectable Hydrogel; Dopamine-Thiol Interaction; Hyaluronic Acid
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| E-Mail |
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