| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
The effect of Enhancer on the Permeation of Indapamide |
| 초록 |
Indapamide is an oral antipertensive diuretic agent indicated for the treatment of hypertensive and edema. Indapamide inhibits carbonic anhydrase enzyme. Transdermal drug delivery systems, as compared to their corresponding classical oral or injectable dosage form counterparts, offer many advantages. In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of Indapamide, the skin permeation rates of Indapamide from vehicles of different composition were determined using Franz cells fitted with excised hairless skins. Solubility of Indapamide in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of Indapamide. The solvents used were Tween80, Tween20, Labrasol®, Lauroglycol90(LG90) and Peceol. |
| 저자 |
서희1, 최혜정1, 박지선1, 황성주2, 육순홍1, 조선행1
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| 소속 |
1한국화학(연), 2충남대 |
| 키워드 |
Indapamide; Enhancer; Transdermal drug delivery systems; Permeability
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| E-Mail |
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