| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Design of hollow PAH/DP nanocapsule as a drug carrier for effective human cancer therapy |
| 초록 |
Photodynamic therapy (PDT) is a promising method for the treatment of several diseases including cancer. It involves the systemic administration of photosensitizers(PSs) such as porphyrin, followed by local photoirradiation with the light of a specific wavelength. In this work, a 3rd generation dendrimer porphyrin with 32 carboxyl groups on the periphery was used as a component to prepare a layer-by-layer structure via an electrostatic adsorption using its anionic peripheral groups. To enhance the efficacy and tumor-specificity of PDT, poly(allylamine hydro chloride) (PAH) / DP nanocarrier was constructed through a LbL self-assembly of PAH and DP on a removable template. It has been reported that the optimal size of drug carriers for efficient delivery of an antitumor agent to a tumor is round 100-200nm. We chose the monodispersed polystyrene nanoparticles with a diameter of 200nm which can be dissolved in chloroform |
| 저자 |
손경진, 김주호, 윤희재, 이열, 박상필, 장은지, 이현종, 남승희, 장우동, 고원건
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| 소속 |
연세대 |
| 키워드 |
drug delivery system(dds); layer-by-layer deposition; photodynamic therapy(PDT); dendrimer porphyrin
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| E-Mail |
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