| 초록 |
Despite of much efforts, the technological efforts still encounter crucial challenges minimizing adverse side effects and implantation failures. In this study, versatile coating of cell-derived extracellular matrices was investigated and applied to a medical device for the purpose of implantation application. First, direct coating of robust extracellular matrices (ECMs) on substrates via two-step surface treatments and decellularization was developed and characterized in terms of chemical, mechanical and biological properties. Results reveal that the coated matrix tightly bound to a substrate has overachieving stability and biologically active effects. Second, the newly developed method was applied to coronary stent device to assess clinical feasibility of our ECM coating. In-vivo results demonstrate that coating is comparatively stable over all procedures of preparation and in vivo application and has promising outcomes in vascular healing and anti-thrombosis. |
