| 학회 |
한국공업화학회 |
| 학술대회 |
2014년 가을 (11/12 ~ 11/14, 엑스코(대구)) |
| 권호 |
18권 2호 |
| 발표분야 |
(국제협력위원회)우수 외국인 연구자를 위한 세션 |
| 제목 |
Light-ROS sensitive Poly(1,4-phenyleneacetone dimethylene thioketal)-Poly(ethylene glycol) (PPADT-PEG) PPADT-PEG Block Copolymers Micelle for Drug Delivery |
| 초록 |
A light, as well as Reactive Oxygen Species (ROS), sensitive polymeric micelle composed of poly(1,4-phenyleneacetone dimethylene thioketal)-poly(ethylene glycol) (PPADT-PEG) block copolymer for drug delivery is introduced here. The ROS sensitive PPADT was synthesized via polycondensation and conjugated to methoxy-PEG. Upon exposure to visible light (λ = 650 nm), the encapsulated meso-tetraphenyl-porphyrin (TPP) released ROS to break down PPADT and free the paclitaxel within the PPADT-PEG micelle core. For anti-cancer purposes, paclitaxel and TPP were encapsulated within the micelle core and its surface decorated with folic acid. Under light irradiation, paclitaxel is released to eradicate cancer cells. This hybrid light-ROS sensitive micelle is a potential drug carrier. Acknowledgement: Korea Health Technology R&D Project (A111552). |
| 저자 |
Geok Leng Seah, 남윤성
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| 소속 |
Korea Advanced Institute of Science and Technology |
| 키워드 |
Light sensitive; ROS; PPADT; polymeric micelle
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| E-Mail |
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