| 초록 |
Theranosis is a term for the combination of diagnosis and therapy. Here, we developed cell-integrated poly(ethylene glycol) hydrogels for in vivo optogenetic sensing and therapy. Real-time optical readout of encapsulated heat-shock-protein-coupled fluorescent reporter cells made it possible to measure the nanotoxicity of cadmium-based quantum dots in vivo. Using optogenetic cells producing glucagon-like peptide-1, we performed light-controlled therapy and obtained improved glucose homeostasis in diabetic model mice. Finally, we developed a smart contact lens composed of biosensors, drug delivery systems, and power sources for the treatment of diabetic retinopathy as a model disease. This presentation will provide the current state-of-the-art smart theranostic systems for further clinical applications. |
