| 초록 |
An orally disintegrating film (ODF) is one of the attractive drug delivery systems due to its fast dissolution and convenience. Solution casting is used to commonly prepare ODF. In this study, two types of ODF were fabricated according to the solvent evaporation rate and the compositions of drug solutions for evaporative crystallization. When acetaminophen was used as a model drug, ethyl cellulose(EC), polyethylene glycol(PEG), polyethylenimine(PEI) and polyvinylpyrrolidone(PVP) were used. The crystal habits of acetaminophen were overlapped triangles, and changed into rod or thick band shapes depending on the types of polymers. When aripiprazole was used as a model drug, PVP were used as a film forming material. In this case, ODF was made using anisole/water emulsions. As a result, we could develop micron-size crystals grown inside anisole droplets. The composite crystals of drug and polymer could be designed to adapt a uniform morphology by controlling the evaporation rate. |
