| 초록 |
Novel thermoresponsive double-hydrophilic fluorinated block copolymers were successfully synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Poly[N-(2,2-difluoroethyl)acrylamide] (P2F) was synthesized via RAFT polymerization of N-(2,2-difluoroethyl)acrylamide (M2F) using DMP as the chain transfer agent (CTA) and AIBN as the initiator. The resulting P2F macroCTA was further chain extended with N-(2-fluoroethyl)acrylamide (M1F) to yield poly{[N-(2,2-difluoroethyl)acrylamide]-b-[N-(2-fluoroethyl)acrylamide]} (P2F-b-P1F) block copolymers with different lengths of the P1F block. Mn and PDI were determined by GPC. Turbidimetry by UV-vis spectroscopy, DLS. Transmission electron microscopy (TEM) studies demonstrated that polymeric aggregates formed. Temperature-triggered release of a model hydrophobic drug, coumarin 102, was also demonstrated. |
