| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 봄 (04/27 ~ 04/29, 부산 BEXCO) |
| 권호 |
22권 1호, p.415 |
| 발표분야 |
생물화공 |
| 제목 |
Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing |
| 초록 |
Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of mussels; 3,4-dihydroxy-L-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications. |
| 저자 |
김효정1, 황병희1, 임성혜1, 최봉혁1, 강석호2, 차형준1
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| 소속 |
1포항공과대, 2고려대 |
| 키워드 |
의약생물공학 |
| E-Mail |
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| 원문파일 |
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