| 초록 |
Self-assembled hydrogel nanoparticles, composed of biocompatible and amphiphilic polymers, have exhibited prolonged circulation in the blood and the preferential accumulation at the tumor tissues when they are systemically administrated in vivo. In this study, we synthesized amphiphilic hyaluronic acids (HA)s as potential drug carriers capable of being self-assembled in an aqueous environment. In an attempt to endow HA with amphiphilicity, the hydrophobic bile acid was conjugated to the backbone of HA. Characterized were the particle size, morphology, and stability of HA-based nanoparticles. Thereafter, in vivo biodistribution of nanoparticles in the tumor-bearing mice was visualized as a function of time using the optical imaging techniques, for which HA derivatives were labeled with the near-infrared (NIR) dye. The quantitative analysis of biodistribution was also carried out using dissected organs. |
