| 초록 |
We visualized the albumin adsorption from the top to the interface with phospholipid monolayer, to understand their dynamics and the effects of the serum albumins on the phospholipids. It is known that the serum albumin in the blood inhibits the lung surfactant and leads to respiratory failure, but it was never investigated before that what happen if albumin in blood flow directly to the alveoli surface through airway, not from the aqueous alveolar fluid. When the droplet of the serum albumin coalesces with phospholipid monolayer, the serum albumin leaves a ‘scar’ at the interface. This scar-like layer has radial fingering patterns, and it is very stable. The structures are not completely disappeared for more than 3 hours even above 20 mN/m, the equilibrium surface pressure of the albumin. The stable albumin layers are observed when the albumin concentration is above 0.05 mg/ml, and it is very critical value to patients considering that ~40 mg/ml of albumin is in the blood. |
