| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.288 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effect of Water-Soluble Additives on Release Profile of BCNU from PLGA Wafer |
| 초록 | 1,3-bis(2-chloroethyl)-1-nitrosourea(BCNU) is an effective chemotherapeutic agent which has been used clinically for treating malignant glioma. Poly(DL-lactide-co-glycolide)(PLGA) is a well known biodegradable polymer used for drug delivery system as drug carrier. In this study, we investigated the effect of water-soluble excipients such as poly(vinylpyrrolidone)(PVP) or sodium chloride incorporated into BCNU/PLGA on release profiles of BCNU. BCNU loaded PLGA wafers with or without excipients were fabricated by direct compression and In vitro release of BCNU from the wafer was assayed by high performance liquid chromatography (HPLC). Initial release amount and release rate of BCNU increased with increase of PVP or NaCl amount. Molecular weight change, mass loss, morphological change of wafer, and pH of release test media were characterized to investigate the effect of PVP or NaCl on both drug release profile and degradation behavior of wafer. Acknowledgment: This work was supported by KMOCIE |
| 저자 | 안태군1, 이진수2, 문대식3, 강희정, 장우영*, 강길선, 성하수 **, 이해방** |
| 소속 | 1전북대, 2*전북대, 3**한국화학(연) |
| 키워드 | |
