| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Theranostic Carbon Nano-Onion Nanopods for Magnetic Resonance Imaging Guided Photothermal therapy |
| 초록 |
Carbon based fluorescent nanomaterials have gained significant interest in recent times because of their biocompatibility and enhanced biological fluorescence property. Here, we developed water soluble white-light-emitting carbon nano-onions (WCNOs) and present them as a novel multi-channel fluorescent nanomaterial for biomedical applications. The developed WCNOs possessed fullerene like structures with 5-8 concentric rings. Moreover, the synthesized WCNOs displayed multi-channel excitation dependent emission in blue, green and red channels. We further coated the surface of WCNOs with manganese oxide (WCNO-MnO2) to develop Hydrogen peroxide responsive bioimaging and biosensing nanomaterials. Interestingly, WCNOs and WCNO-MnO2 displayed photothermal activity under NIR irradiation. WCNO-MnO2 displayed enhanced heat generation compared to WCNO. In vivo PTT results indicates WCNO-MnO2 as an efficient PTT agent that can prevent cancer progression. |
| 저자 |
Vishnu Revuri1, 이용규2
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| 소속 |
1Korea National Univ. of Transportation, 2한국교통대 |
| 키워드 |
Carbon Nano-Onions; Manganese Oxide; Photothermal therapy; Hydrogen peroxide; Magnetic Resonance Imaging
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| E-Mail |
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