| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Gold-deposited Iron oxide/Glycol Chitosan Composite Nanoparticles for Magnetic Resonance Imaging Agent of Characteristic |
| 초록 |
We report the preparation of gold-deposited iron oxide/glycol chitosan composite nanoparticles and their characterization as a magnetic resonance (MR) imaging agent with tumor targeting characteristic. Gold deposited iron oxide/glycol chitosan complex was formed by ionic interactions between chitosan and gold nanoparticles and was freeze-dried to prepare gold-iron/chitosan composite nanoparticles in the powdery state. TEM (Transmittance Electron Microscopy) and a ELS (Electrophoretic Light Scattering) were used to observe the formation of stabilized composite nanoparticles. To observe the MRI (Magnetic Resonance Imaging) contrast characteristic, the composite nanoparticles were injected into the tail veins of tumor-bearing mice to demonstrate their selective tumoral distribution and long stability in blood circulation. MR images were collected with conventional T2-weighted spin echo acquisition parameters. |
| 저자 |
송병철1, 오근상1, 육순홍1, 이범석2, 김상윤3
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| 소속 |
1한남대, 2울산의과대, 3아산생명과학(연) |
| 키워드 |
glycol chitosan; Magnetic resonance imaging agent; Tumor targeting; Heparin; Pluronic F-68
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| E-Mail |
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