| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Natural Scaffolds for retinal pigment epithelial cells in vitro |
| 초록 |
Transplantation of retinal pigment epithelial (RPE) cells is a promising treatment modality to repair retinal damage in age-related degeneration. For this purpose, it is necessary to establish cell culture techniques that allow acquisition of proper functional and morphological characteristics. The transplantation of RPE cells requires that the transplanted cells form a monolayer in the subretinal space. Since previous studies have shown that transplanted cells in suspension do not form a monolayer, it will be necessary to transplant preformed RPE cell monolayers at the location of the exposed photoreceptors. To establish cell monolayers, RPE cells were cultured on SIS sheets. Cells were examined for morphology, for characteristics of differentiation and viability on SIS sheet. These studies revealed that RPE cells adhere, proliferate, form monolayers. These scaffolds can support an intact functional monolayer of healthy differentiated RPE cells. |
| 저자 |
정수미, 김수진, 김은영, 조은혜, 오명준, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Transplantation; retinal pigment epithelial cells; SIS sheet
|
| E-Mail |
|
