| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Study of Photo-reactive Azidophenyl O-Carboxymethyl Chitosan Derivatives For Medical Application of Protein-immobilization |
| 초록 |
According to medical advances, biomaterial was also researched and developed. Natural polymers were emerged as a new generation in biomaterial because natural polymers have less toxic, biodegradable, biocompatible. To inspect the effect photo-immobilized chitosan, o-carboxymethyl chitosan derivatives was prepared for introducing azido group. The prepared azidophenyl o-carboxymethyl chitosan (Az-O-CMC) derivatives were confirmed the characterization by FT-IR, NMR. The photo-reactive Az-O-CMC was investigated for hardening rate and cross-linking maintainability. Photo-mask was used for observation of photo-immobilization and the cytotoxicity of Az-O-CMC was confirmed by MTT assay. 3T3-L1 cells cultured upon the plate to determine for adhesion between cell and photo-immobilized Az-O-CMC. The present study provided the characterization of Az-O-CMC derivatives and indicated that immobilization of Az-O-CMC will be useful for medical application of protein-immobilization. |
| 저자 |
허윤, 박신혜, 이형재, 조영민, 김은혜, 손태일
|
| 소속 |
중앙대 |
| 키워드 |
Chitosan; Carboxymethyl; Photoreactive; Azidophenyl; protein-immobilization; biomaterials
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| E-Mail |
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