| 초록 |
The development of cell-culture platform equipped with stretchable electronics to embrace in vitro cell cultures, directional organizations, and physiological monitoring as well as in vivo applications in tissue regeneration has been an overarching goal. Although many concepts of platforms for cell culturing has been studied, an integrated system featured with these multi-functionalities is not reported yet. Here, we present an instrumented cell-culture platform, composed of nano-membrane sensors and graphene nanoribbons on a soft elastomeric substrate. Main objectives are i) inducing aligned cellular proliferation and differentiation on graphene nanoribbons, ii) monitoring cellular activities via soft nano-membrane sensors, iii) effectuating the muscle-on-a-chip as an in vitro testing tool, and iv) performing cell sheet treatments using new transfer printing techniques. This development would contribute to broadening the applicability of tissue engineering and regenerative medicine. |
