| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Electropolymerization of Drug-containing Polymers |
| 초록 |
Restenosis after e.g.percutane coronar interventions is still a problem in angioplasty. Introduction of coated stents was a significant progress in suppression of cellular proliferation. But, most of the paclitaxel-eluting stents are layer by layer coatings by a physical absortion. It raise a problem in suppression of effectively cellular proliferation. Therefore, the development of tailored drug-eluting stent(DES) are on demand and is still a challenge for materials science and engineering. In this study, water soluble paclitaxel prodrug(PP7) analogues synthesized by incorporation of hexenoate with vinyl group onto the carbon 2’ of water soluble paclitaxel prodrug(PP7). And water soluble paclitaxel prodrug(PP7) analogues synthesized were polymerized directly on-to the surface of a stainless-steel by an electrochemical polymerization that is initiated in-situ at the surface. It could be of anti-restenotic and anti-proliferating coatings for medical application of paclitaxel. |
| 저자 |
최은선1, 손정선1, 조병욱1, Michael Hess2, 최재곤1
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| 소속 |
1조선대, 2Univ. of Duisburg-Essen |
| 키워드 |
electropolymerization; paclitaxel
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| E-Mail |
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