| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dexamethasone loaded and biodegradable core-sheath biphasic monofilaments: Drug release and degradation studies |
| 초록 |
Although biodegradable polymeric filaments have been widely used for biomedical applications, these still have some problems such as inflammation and mechanical properties. In our previous study, poly(L-lactide)-polydioxanone (PLLA-PDO) core-sheath monofilaments have been developed and characterized. In this study, mechanical properties, biodegradability, and the drug release of series of PLLA-PDO core-sheath monofilaments containing dexamethasone (Dex), an anti-inflammatory drug, were investigated. Biphasic structures showed the advancement of mechanical properties in the degradation process. Biodegradation could be controlled by biphasic structure and drawing process. PLLA-PDO monofilaments released Dex in sustained or controlled manners through the drug location in the biphasic structure and drawing rates. In conclusion, our drug-eluting sheath-core monofilament stents can be a promising model for advanced nonvascular stents, the targeted application of this study. |
| 저자 |
양승원1, Myoung Jin Jang2, 손준식3, 정윤기1
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| 소속 |
1한국과학기술(연), 2한국섬유(연), 3한국섬유개발(연) |
| 키워드 |
core-sheath monofilament; drug-eluting stent; polydioxanone; poly (L-lactic acid)
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| E-Mail |
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