| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Enhanced solubility of flavonoids through formation of nanocomplex with PEG for ocular diseases |
| 초록 |
Flavonoid is one of the polyphenolic molecule from natural species such as fruit and plant. Bio-inspired compound, catechin, is one of the component from green tea and other plants. Catechin as well as other flavonoids are generally known for their advantageous properties such as anti-inflammation, anti-oxidant, and anti-cancer effects. Many flavonoids are poorly soluble in water which is a critical drawback to be used in bio-applications. In this study, we increased aqueous solubility of catechin through formation of complex with poly(ethylene glycol) (PEG). The experimental procedure does not require chemical cross-linker or initiator. The preparation is simple but the solubility enhancement is high (at least 50 mg/ml). Nanocomlex of catechin is used in in-vivo to treat dry eye model. The nanocomplex showed anti-inflammation property and increased goblet cell density which helps dry eye diseases. |
| 저자 |
심휘수1, Hye Sook Lee2, Jae Wook Yang2, 이해신1
|
| 소속 |
1KAIST, 2Inje Univ. Busan Paik Hospital |
| 키워드 |
solubilization |
| E-Mail |
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